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生物通商城首頁 > 試劑 > 細胞生物學 > 藥物代謝分析 > P450抑制分析試劑盒

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Corning® Supersomes™ P450 抑制試劑盒(CYP2D6/AMMC)/ Corning® Supersomes™ P450 Inhibition Kit CYP2D6/AMMC 1 Kit

價格:¥

貨号:459200
品牌:Gentest

經銷:基因生物技術國際貿易(上海)有限公司

P450抑制試劑盒Kit,可快速檢測細胞因子P450催化活性被抑制的情況。體系中含有檢測CYP2D6-AMMC半抑制因子IC50的所有組分,甲基香豆素AMMC為熒光底物,奎尼丁作為陽性抑制對照,38 test/kit,适用于96、384、1536孔闆。-80℃保存,盡量避免反複凍融。 This kit rapidly screen for potential inhibitors of cytochrome P450 catalytic activity. The kit provides all necessary components for measuring the IC50 value for up to 38 test compounds in 96 well plates. The kit can accommodate other plate formats, e.g. 384 and 1536 well, with proper scaling.

Kit Components
• CYP2D6 + P450 Reductase
• Control: Insect Cell Membrane Protein
• Buffer Solution: 0.5 M Potassium Phosphate (pH 7.4), filter sterilized
• Stop Solution: 0.5 M Tris Base, filter sterilized
• Cofactors: 1.3 mM NADP+, 66 mM MgCl2, and 66 mM Glucose 6-Phosphate
• Glucose 6-Phosphate Dehydrogenase: 40 units/mL in 5 mM Sodium Citrate Buffer (pH 7.5)
• AMMC (3-[2-(N,N-diethyl-N-methylamino)ethyl]-7-methoxy-4-methylcoumarin): Fluorescence substrate, 0.302 mg
• Quinidine: CYP2D6 selective positive control inhibitor, 0.0006 mg
• AHMC (3-[2-(N,N-diethylamino)ethyl]-7-hydroxy-4-methylcoumarin hydrochloride): Metabolite standard (10 uM in water)
Preparation and Storage Store at -80°C

Corning® Supersomes™ P450抑制試劑盒(CYP3A4/BFC)/ Corning® Supersomes™ P450 Inhibition Kit CYP3A4/BFC 1 Kit

價格:¥

貨号:459100
品牌:Gentest

經銷:基因生物技術國際貿易(上海)有限公司

P450抑制試劑盒Kit,可快速檢測細胞因子P450催化活性被抑制的情況。體系中含有檢測CYP3A4-BFC半抑制因子IC50的所有組分,BFC為熒光底物,酮康唑為陽性抑制對照,38 test/kit,适用于96、384、1536孔闆。-80℃保存,盡量避免反複凍融。 This kit rapidly screen for potential inhibitors of cytochrome P450 catalytic activity. The kit provides all necessary components for measuring the IC50 value for up to 38 test compounds in 96 well plates. The kit can accommodate other plate formats, e.g. 384 and 1536 well, with proper scaling.

Kit Components:
• CYP3A4 + P450 Reductase + Cytochrome b5
• Control: Insect Cell Membrane Protein
• Buffer Solution: 0.5 M Potassium Phosphate (pH 7.4), filter sterilized
• Stop Solution: 0.5 M Tris Base, filter sterilized
• Cofactors: 1.3 mM NADP+, 66 mM MgCl2, and 66 mM Glucose 6-Phosphate
• Glucose 6-Phosphate Dehydrogenase: 40 units/mL in 5 mM Sodium Citrate Buffer (pH 7.5)
• BFC (7-Benzyloxy-trifluoromethylcoumarin)#: Fluorescence substrate, 4.3 mg
• KTZ (Ketoconazole): CYP3A4 selective positive control inhibitor, 0.008 mg
• HFC (7-Hydroxytrifluoromethylcoumarin): Metabolite standard (0.25 mM in 0.1 M Tris-pH 9.0)

Note
• Freeze/thaw stability: This CYP3A4 inhibitor screening kit was subjected to 10 freeze/thaw cycles without a change in IC50 value for ketoconazole or a significant loss of signal to noise
Preparation and Storage Store at -80°C

Corning® Supersomes™ P450抑制試劑盒(CYP2C9/MFC)/ Corning® Supersomes™ P450 Inhibition Kit CYP2C9/MFC 1 Kit

價格:¥

貨号:459300
品牌:Gentest

經銷:基因生物技術國際貿易(上海)有限公司

P450抑制試劑盒Kit,可快速檢測細胞因子P450催化活性被抑制的情況。體系中含有檢測CYP2C9-MFC半抑制因子IC50的所有組分,甲基香豆素MFC為熒光底物,硫胺苯吡唑SFZ作為陽性抑制對照,38 test/kit,适用于96、384、1536孔闆。-80℃保存,盡量避免反複凍融。 This kit rapidly screens for potential inhibitors of cytochrome P450 catalytic activity. The kit provides all necessary components for measuring the IC50 value for up to 38 test compounds in 96 well plates. The kit can also accommodate other plate formats, e.g. 384 and 1536 well, with proper scaling.

Kit Components:
• CYP2C9 + P450 Reductase + Cytochrome b5
• Control: Insect Cell Membrane Protein
• Buffer Solution: 0.5 M Potassium Phosphate (pH 7.4), filter sterilized
• Stop Solution: 0.5 M Tris Base, filter sterilized
• Cofactors: 1.3 mM NADP+, 66 mM MgCl2, and 66 mM Glucose 6-Phosphate
• Glucose 6-Phosphate Dehydrogenase: 40 units/mL in 5 mM Sodium Citrate Buffer (pH 7.5)
• MFC (7-Methoxy-trifluoromethylcoumarin): Fluorescence substrate, 5.5 mg
• SFZ (Sulfaphenazole): CYP2C9 selective positive control inhibitor, 0.0094 mg
• HFC (7-Hydroxytrifluoromethylcoumarin): Metabolite standard (0.25 mM in 0.1 M Tris-pH 9.0)

Corning® Supersomes™ P450抑制試劑盒(CYP2C19/CEC)/ Corning® Supersomes™ P450 Inhibition Kit CYP2C19/CEC 1 Kit

價格:¥

貨号:459400
品牌:Gentest

經銷:基因生物技術國際貿易(上海)有限公司

P450抑制試劑盒Kit,可快速檢測細胞因子P450催化活性被抑制的情況。體系中含有檢測CYP2C19/CEC半抑制因子IC50的所有組分,3-氰基-7-乙氧基香豆素CEC為熒光底物,TCP作為陽性抑制對照,38 test/kit,适用于96、384、1536孔闆。-80℃保存,盡量避免反複凍融。 This kit rapidly screen for potential inhibitors of cytochrome P450 catalytic activity. The kit provides all necessary components for measuring the IC50 value for up to 38 test compounds in 96 well plates. The kit can accommodate other plate formats, e.g. 384 and 1536 well, with proper scaling.

Kit Components:
• CYP2C19 + P450 Reductase + Cytochrome b5
• Control: Insect Cell Membrane Protein
• Buffer Solution: 0.5 M Potassium Phosphate (pH 7.4), filter sterilized
• Stop Solution: 0.5 M Tris Base, filter sterilized
• Cofactors: 1.3 mM NADP+, 66 mM MgCl2, and 66 mM Glucose 6-Phosphate
• Glucose 6-Phosphate Dehydrogenase: 40 units/mL in 5 mM Sodium Citrate Buffer (pH 7.5)
• CEC (3-Cyano-7-Ethoxycoumarin): Fluorescence substrate, 1.5 mg
• TCP (Tranylcypromine): CYP2C19 selective positive control inhibitor, 0.0509 mg
• CHC (3-Cyano-7-Hydroxycoumarin): Metabolite standard (10 uM in water)

Corning® Supersomes™ P450抑制試劑盒(CYP3A4/BQ)/Corning® Supersomes™ P450 Inhibition Kit CYP3A4/BQ 1 Kit

價格:¥

貨号:459110
品牌:Gentest

經銷:基因生物技術國際貿易(上海)有限公司

P450抑制試劑盒Kit,可快速檢測細胞因子P450催化活性被抑制的情況。體系中含有檢測CYP3A4-BQ半抑制因子IC50的所有組分,38 test/kit,适用于96、384、1536孔闆。-80℃保存,盡量避免反複凍融。 This kit rapidly screen for potential inhibitors of cytochrome P450 catalytic activity. The kit provides all necessary components for measuring the IC50 value for up to 38 test compounds in 96 well plates. The kit can accommodate other plate formats, e.g. 384 and 1536 well, with proper scaling.

Kit Components:
• CYP3A4 + P450 Reductase + Cytochrome b5
• Control: Insect Cell Membrane Protein
• Buffer Solution: 0.5 M Potassium Phosphate (pH 7.4), filter sterilized
• Stop Solution: 0.5 M Tris Base, filter sterilized
• Cofactors: 1.3 mM NADP+, 66 mM MgCl2, and 66 mM Glucose 6-Phosphate
• Glucose 6-Phosphate Dehydrogenase: 40 units/mL in 5 mM Sodium Citrate Buffer (pH 7.5)
• BQ (7-Benzyloxyquinoline): Fluorescence substrate, 2.68 mg
• KTZ (Ketoconazole): CYP3A4 selective positive control inhibitor, 0.008 mg
• HQ (7-Hydroxyquinoline): Metabolite standard (0.5 mM in 0.05 M Potassium Phosphate)
Note • Freeze/thaw stability: This CYP3A4 inhibitor screening kit was subjected to 10 freeze/thaw cycles without a change in IC50 value for ketoconazole or a significant loss of signal to noise
Preparation and Storage Store at -80°C

Corning® Supersomes™ P450抑制試劑盒(CYP3A4/DBF)/ Corning® Supersomes™ P450 Inhibition Kit CYP3A4/DBF 1 Kit

價格:¥

貨号:459120
品牌:Gentest

經銷:基因生物技術國際貿易(上海)有限公司

P450抑制試劑盒Kit,可快速檢測細胞因子P450催化活性被抑制的情況。體系中含有檢測CYP3A4-DBF半抑制因子IC50的所有組分,38 test/kit,适用于96、384、1536孔闆。-80℃保存,盡量避免反複凍融。 This kit rapidly screen for potential inhibitors of cytochrome P450 catalytic activity. The kit provides all necessary components for measuring the IC50 value for up to 38 test compounds in 96 well plates. The kit can accommodate other plate formats, e.g. 384 and 1536 well, with proper scaling.
Kit Components: • CYP3A4 + P450 Reductase + Cytochrome b5 • Control: Insect Cell Membrane Protein • Buffer Solution: 0.5 M Potassium Phosphate (pH 7.4), filter sterilized • Cofactors: 1.3 mM NADP+, 66 mM MgCl2, and 66 mM Glucose 6-Phosphate • Glucose 6-Phosphate Dehydrogenase: 40 units/mL in 5 mM Sodium Citrate Buffer (pH 7.5) • DBF (Dibenzylfluorescein): Fluorescence substrate, 0.15 mg • KTZ (Ketoconazole): CYP3A4 selective positive control inhibitor, 0.008 mg • Fluorescein: Metabolite standard (10 µM in distilled water) Note: • Freeze/thaw stability: This CYP3A4 inhibitor screening kit was subjected to 10 freeze thaw cycles without a change in IC50 value for ketoconazole or a significant loss of signal to noise • xx = Actual values can be found on the data sheet accompanying each shipped product Preparation and Storage Store at -80°C

Corning® Supersomes™ P450抑制試劑盒(CYP1A2/CEC)/ Corning® Supersomes™ P450 Inhibition Kit CYP1A2/CEC 1 Kit

價格:¥

貨号:459500
品牌:Gentest

經銷:基因生物技術國際貿易(上海)有限公司

P450抑制試劑盒Kit,可快速檢測細胞因子P450催化活性被抑制的情況。體系中含有檢測CYP1A2/CEC半抑制因子IC50的所有組分,3-氰基-7-乙氧基香豆素CEC為熒光底物,呋喃茶堿作為陽性抑制對照,38 test/kit,适用于96、384、1536孔闆。-80℃保存,盡量避免反複凍融。 This kit rapidly screen for potential inhibitors of cytochrome P450 catalytic activity. The kit provides all necessary components for measuring the IC50 value for up to 38 test compounds in 96 well plates. The kit can accommodate other plate formats, e.g. 384 and 1536 well, with proper scaling.

Kit Components:
• CYP1A2 + P450 Reductase
• Control: Insect Cell Membrane Protein
• Buffer Solution: 0.5 M Potassium Phosphate (pH 7.4), filter sterilized
• Stop Solution: 0.5 M Tris Base, filter sterilized
• Cofactors: 1.3 mM NADP+, 66 mM MgCl2, and 66 mM Glucose 6-Phosphate
• Glucose 6-Phosphate Dehydrogenase: 40 units/mL in 5 mM Sodium Citrate Buffer (pH 7.5)
• CEC (3-Cyano-7-Ethoxycoumarin): Fluorescence substrate, 0.43 mg
• Furafylline : CYP1A2 selective positive control inhibitor, 0.078 mg
• CHC (3-Cyano-7-Hydroxycoumarin): Metabolite standard (10 uM in water)

Corning® Supersomes™ P450抑制試劑盒(CY2C8/DBF)/ Corning® Supersomes™ P450 Inhibition Kit CY2C8/DBF 1 Kit

價格:¥

貨号:459320
品牌:Gentest

經銷:基因生物技術國際貿易(上海)有限公司

P450抑制試劑盒Kit,可快速檢測細胞因子P450催化活性被抑制的情況。體系中含有檢測CY2C8/DBF半抑制因子IC50的所有組分,DBF為熒光底物,五羟黃酮作為陽性抑制對照,38 test/kit,适用于96、384、1536孔闆。-80℃保存,盡量避免反複凍融。 This kit rapidly screen for potential inhibitors of cytochrome P450 catalytic activity. The kit provides all necessary components for measuring the IC50 value for up to 38 test compounds in 96 well plates. The kit can accommodate other plate formats, e.g. 384 and 1536 well, with proper scaling.

Kit Components:
• CYP2C8 + P450 Reductase + Cytochrome b5
• Control: Insect Cell Membrane Protein
• Buffer Solution: 0.5 M Potassium Phosphate (pH 7.4), filter sterilized
• Cofactors: 1.3 mM NADP+, 66 mM MgCl2, and 66 mM Glucose 6-Phosphate
• Glucose 6-Phosphate Dehydrogenase: 40 units/mL in 5 mM Sodium Citrate Buffer (pH 7.5)
• DBF (Dibenzylfluorescein): Fluorescent substrate, 0.15 mg
• Quercetin: CYP2C8 selective positive control inhibitor, 0.02 mg
• Fluorescein: Metabolite standard (10 uM in distilled water)

Note:
• Freeze/thaw stability: This CYP2C8 inhibitor screening kit was subjected to 10 freeze/thaw cycles without a change in IC50 value for Quercetin or a significant loss of signal to noise
• 2N NaOH cannot be shipped because it is a hazardous chemical. Refer to Instruction manual for the method of preparation
• XX = Actual values can be found on the data sheet accompanying each shipped product
Preparation and Storage Store at -80°C

Corning® Supersomes™ P450抑制試劑盒(CYP2B6/EFC)/ Corning® Supersomes™ P450 Inhibition Kit CYP2B6/EFC 1 Kit

價格:¥

貨号:459220
品牌:Gentest

經銷:基因生物技術國際貿易(上海)有限公司

P450抑制試劑盒Kit,可快速檢測細胞因子P450催化活性被抑制的情況。體系中含有檢測 CYP2B6-EFC半抑制因子IC50的所有組分,EFC為熒光底物,苯環丙胺TCP作為陽性抑制對照,38 test/kit,适用于96、384、1536孔闆。-80℃保存,盡量避免反複凍融。 This kit rapidly screen for potential inhibitors of cytochrome P450 catalytic activity. The kit provides all necessary components for measuring the IC50 value for up to 38 test compounds in 96 well plates. The kit can accommodate other plate formats, e.g. 384 and 1536 well, with proper scaling.

Kit Components:
• CYP2B6 + P450 Reductase + Cytochrome b5
• Control: Insect Cell Membrane Protein
• Buffer Solution: 0.5 M Potassium Phosphate (pH 7.4), filter sterilized
• Stop Solution: 0.5 M Tris Base, filter sterilized
• Cofactors: 1.3 mM NADP+, 66 mM MgCl2, and 66 mM Glucose 6-Phosphate
• Glucose 6-Phosphate Dehydrogenase: 40 units/mL in 5 mM Sodium Citrate Buffer (pH 7.5)
• EFC (7-Ethoxy-4-trifluoromethylcoumarin): Fluorescence substrate, 0.39 mg
• TCP (Tranylcypromine): CYP2B6 selective positive control inhibitor, 0.2546 mg
• HFC (7-Hydroxytrifluoromethylcoumarin): Metabolite standard (0.25 mM in 0.1 M Tris-pH 9.0)
Preparation and Storage Store at -80°C

Corning® Supersomes™ P450抑制試劑盒(CYP19/MFC)/ Corning® Supersomes™ P450 Inhibition Kit CYP19/MFC 1 Kit

價格:¥

貨号:459520
品牌:Gentest

經銷:基因生物技術國際貿易(上海)有限公司

P450抑制試劑盒Kit,可快速檢測細胞因子P450催化活性被抑制的情況。體系中含有檢測CYP19/MFC半抑制因子IC50的所有組分,MFC為熒光底物,酮康唑HFC作為陽性抑制對照,38 test/kit,适用于96、384、1536孔闆。-80℃保存,盡量避免反複凍融。 This kit rapidly screen for potential inhibitors of cytochrome P450 catalytic activity. The kit provides all necessary components for measuring the IC50 value for up to 38 test compounds in 96 well plates. The kit can accommodate other plate formats, e.g. 384 and 1536 well, with proper scaling.

Kit Components:
• CYP19 + P450 Reductase
• Control: Insect Cell Membrane Protein
• Buffer Solution: 0.5 M Potassium Phosphate (pH 7.4), filter sterilized
• Stop Solution: 0.5 M Tris Base, filter sterilized
• Cofactors: 1.3 mM NADP+, 66 mM MgCl2, and 66 mM Glucose 6-Phosphate
• Glucose 6-Phosphate Dehydrogenase: 40 units/mL in 5 mM Sodium Citrate Buffer (pH 7.5)
• MFC (7-Methoxy-trifluoromethylcoumarin): Fluorescence substrate, 1.21 mg
• KTZ (Ketaconazole): CYP19 selective positive control inhibitor, 0.032 mg
• HFC (7-Hydroxytrifluoromethylcoumarin): Metabolite standard (0.25 mM in 0.1 M Tris-pH 9.0)

Corning® Supersomes™ P450抑制試劑盒(CYP2A6/Coumarin)Corning® Supersomes™ P450 Inhibition Kit CYP2A6/Coumarin 1 Kit

價格:¥

貨号:459420
品牌:Gentest

經銷:基因生物技術國際貿易(上海)有限公司

P450抑制試劑盒Kit,可快速檢測細胞因子P450催化活性被抑制的情況。體系中含有檢測CYP2A6/Coumarin半抑制因子IC50的所有組分,香豆素為熒光底物,苯環丙胺TCP作為陽性抑制對照,38 test/kit,适用于96、384、1536孔闆。-80℃保存,盡量避免反複凍融。 This kit rapidly screen for potential inhibitors of cytochrome P450 catalytic activity. The kit provides all necessary components for measuring the IC50 value for up to 38 test compounds in 96 well plates. The kit can accommodate other plate formats, e.g. 384 and 1536 well, with proper scaling.

Kit Components
• CYP2A6 + P450 Reductase + Cytochrome b5
• Control: Insect Cell Membrane Protein
• Buffer Solution: 0.5 M Tris (pH 7.5), filter sterilized
• Stop Solution: 0.5 M Tris Base, filter sterilized
• Cofactors: 1.3 mM NADP+, 66 mM MgCl2, and 66 mM Glucose 6-Phosphate
• Glucose 6-Phosphate Dehydrogenase: 40 units/mL in 5 mM Sodium Citrate Buffer (pH 7.5)
• Coumarin: Fluorescence substrate (1.1 mM in deionized water)
• TCP(Tranylcypromine): CYP2A6 selective positive control inhibitor, 0.017 mg
• HC (7-Hydroxycoumarin): Metabolite standard (0.5 mM in 0.1 M Tris, pH 7.5)

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